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(p. 243) Depression and psychoneuroimmunology 

(p. 243) Depression and psychoneuroimmunology
Chapter:
(p. 243) Depression and psychoneuroimmunology
Author(s):

Michael R. Irwin

and Jason C. Cole

DOI:
10.1093/med:psych/9780198568841.003.0010
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date: 20 October 2020

This chapter provides a review of the psychoneuroimmunological research being conducted on the relationship between depression and immunity. The chapter begins with a description of the clinical importance of depressive disorders with attention to the effects of depression on mortality risk. Depression is associated with changes in behaviours such as sleep disturbance that also impact immune function. A detailed review of the research conducted on the various immune findings that occur during depression is provided. Finally, the chapter concludes with a discussion of the clinical implications of immune changes in depression for several medical disorders.

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