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(p. 67) The Unified Protocol for Major Depressive Disorder 

(p. 67) The Unified Protocol for Major Depressive Disorder
(p. 67) The Unified Protocol for Major Depressive Disorder

James F. Boswell

, Laren R. Conklin

, Jennifer M. Oswald

, and Matteo Bugatti

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date: 25 June 2021

Major depressive disorder (MDD) can be a chronic, debilitating condition that for many individuals waxes and wanes over time. In addition, MDD and other unipolar depressive disorders demonstrate a high level of comorbidity with anxiety disorders. This chapter describes the application of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) to MDD and other unipolar depressive disorders. We first review research supporting the association between depression and higher-order constructs such as neuroticism. Next, we present a clinical case that, combined with module-specific recommendations, further illustrates how UP principles and strategies are implemented in the treatment of primary depression. Finally, we offer recommendations for future work involving the UP for major depression and other depressive disorders.

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