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(p. 285) Ethics and Research with Children: Synthesis and Concluding Reflections 

(p. 285) Ethics and Research with Children: Synthesis and Concluding Reflections
(p. 285) Ethics and Research with Children: Synthesis and Concluding Reflections

Robert M. Nelson

and Eric Kodish

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date: 25 May 2020

This chapter explores the ethical tension between protecting vulnerable children from research risks and protecting children through access to appropriate research in support of safe and effective pediatric products. The history of the debate over pediatric research is reviewed briefly, along with central ethical themes within that debate. Each of the chapters in this volume are set within this context. Themes examined include the role of the clinician-investigator, the concept of the best interests of the child, appropriate risk assessment, the importance of component analysis to the assessment of pediatric research protocols, the choice of an appropriate control group, parental permission and child assent, compensating children for research participation, and the fetus as research subject.

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