Show Summary Details
Page of

(p. 329) Stress and Anxiety Disorders 

(p. 329) Stress and Anxiety Disorders
(p. 329) Stress and Anxiety Disorders

Richard McCarty

Page of

PRINTED FROM OXFORD CLINICAL PSYCHOLOGY ONLINE ( © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Clinical Psychology Online for personal use (for details see Privacy Policy and Legal Notice).

date: 25 May 2020

Much of the research relating to animal models of anxiety has been devoted to developing more effective drugs for the treatment of the various anxiety disorders. Using selective breeding of laboratory mice and rats, investigators have developed high-anxiety and low-anxiety lines that have been especially valuable for basic research purposes. Other approaches to enhance the expression of an anxiety-like phenotype have included prenatal or early postnatal exposure to stressors, maternal immune activation, or selecting offspring based upon differences in the maternal behaviors of their mothers. In addition, risk genes for anxiety disorders have been studied in animal models, including genes related to serotonin, neuropeptide Y, neuropeptide S, and corticotropin-releasing factor signaling in the brain. Finally, some infant rhesus monkeys display an anxious temperament and extreme behavioral inhibition when separated from their mothers. This nonhuman primate model affords many opportunities to explore brain mechanisms and interventions that may be effective in preventing the further development of an anxious phenotype as these monkeys mature.

Access to the complete content on Oxford Clinical Psychology requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.