Show Summary Details
Page of

(p. 395) Stress and Depression: Part 2 

(p. 395) Stress and Depression: Part 2
(p. 395) Stress and Depression: Part 2

Richard McCarty

Page of

PRINTED FROM OXFORD CLINICAL PSYCHOLOGY ONLINE ( © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Clinical Psychology Online for personal use (for details see Privacy Policy and Legal Notice).

date: 25 May 2020

This chapter on animal models of depression includes a summary of additional approaches to modeling a depression-like phenotype in animals. Several risk genes have been evaluated, including genes involved in dopamine, serotonin, and corticotropin-releasing factor signaling. Using a two-hit model, some investigators have examined the effects of early life stress combined with stress in adulthood to unmask the risk for a depression-like phenotype. Female mice were more sensitive than male mice to a sub-chronic paradigm of chronic variable stress and displayed depression-like behavioral changes. A naturally occurring depression-like phenotype has also been documented in captive social groups of cynomolgous monkeys. Three additional approaches to study mechanisms involved in the onset of depression have included stress and neurogenesis, stress and epigenetic alterations in gene transcription, and stress and immune signaling through proinflammatory cytokines. Taken together, these experiments have identified multiple potential targets for future drug development.

Access to the complete content on Oxford Clinical Psychology requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.