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(p. 23) Treatment effectiveness 

(p. 23) Treatment effectiveness
(p. 23) Treatment effectiveness

Gavin Andrews

, Alison E. J. Mahoney

, Megan J. Hobbs

, and Margo Genderson

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date: 28 October 2020

This chapter provides a critical review of the literature concerning the efficacy and effectiveness of pharmacotherapy and psychotherapy for adult patients with generalized anxiety disorder (GAD). The review primarily canvases systematic reviews and meta-analyses of randomized controlled trials. Key statistics are reported including number needed to treat, number needed to harm, treatment effect sizes, and adherence proportions. Pharmacotherapies reviewed comprise benzodiazepines, escitalopram, paroxetine, sertraline, duloxetine, venlafaxine, and pregabalin. Psychotherapies reviewed are cognitive behavior therapies (including transdiagnostic and internet-based cognitive behavior therapy, iCBT), relaxation training, and short-term psychodynamic therapy. The review concludes that medications should only be used when psychological treatments have failed, and that cognitive behavior therapy is the psychological treatment of choice.

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