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(p. 327) Pharmacological Treatments for Unipolar Depression 

(p. 327) Pharmacological Treatments for Unipolar Depression
(p. 327) Pharmacological Treatments for Unipolar Depression

Stefania Prendes-Alvarez

, Alan F. Schatzberg

, and Charles B. Nemeroff

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date: 28 October 2020

Major depressive disorder is a chronic syndrome associated with high mortality (secondary to suicide and increased risk for heart disease, stroke, and other serious diseases). It is one of the most common medical disorders affecting adults in the world today. In the United States, the lifetime prevalence of major depression is 16.7% for adults. The average age of onset is 32 years, and women are 70% more likely to develop depression than men. Neither the core requisite symptoms for the diagnosis of a major depressive episode nor the required duration of at least 2 weeks has changed from DSM-IV to DSM-5. This chapter discusses the main issues surrounding the treatment of major depressive disorder, such as suicidality and goals of treatment, and provides information about all treatment options approved by the U.S. Food & Drug Administration. Drugs are categorized by their mechanisms of action.

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