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(p. 871) Psychopharmacological Treatment of Personality Disorders 

(p. 871) Psychopharmacological Treatment of Personality Disorders
(p. 871) Psychopharmacological Treatment of Personality Disorders

M. Mercedes Perez-Rodriguez

and Larry J. Siever

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date: 23 September 2020

Despite the lack of approval by the U.S. Food & Drug Administration, drugs are used widely to treat personality disorders, particularly borderline personality disorder, based on their effects known from clinical trials in other psychiatric disorders (off-label use). The role of medications in personality disorders is limited to moderate effects on some but not all of the symptom domains. There are no medications available that improve the global severity of any personality disorder as a whole. In borderline personality disorder, evidence is strongest for second-generation antipsychotics and mood stabilizers, while dietary supplements like omega-3 fatty acids hold some promise. However, medications have limited effectiveness and are still viewed as adjunctive to other forms of treatment, particularly psychotherapy.

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