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(p. 131) Leptin Gene Therapy for Hyperphagia, Obesity, Metabolic Diseases, and Addiction: A New Opportunity 

(p. 131) Leptin Gene Therapy for Hyperphagia, Obesity, Metabolic Diseases, and Addiction: A New Opportunity
Chapter:
(p. 131) Leptin Gene Therapy for Hyperphagia, Obesity, Metabolic Diseases, and Addiction: A New Opportunity
Author(s):

Satya P. Kalra

DOI:
10.1093/med:psych/9780199738168.003.0019
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date: 20 October 2020

Chapter 19 discusses leptin gene therapy for hyperphagia, obesity, metabolic diseases, and addiction. It includes neural and hormonal circuits in integration of energy homeostasis, leptin insufficiency syndrome, leptin gene therapy to overcome central leptin insufficiency (hyperphagia, fat accumulation, and energy expenditure), and the amelioration of diabetes (repression of pancreating insulin secretion, glucose homeostasis, bone remodelling, cardiovascular disease risks, impact of leptin transgene expression in the hypothalamus of imprinting and life span, craving for food versus drugs of abuse).

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